JUQ‑063 is a non‑covalent, high‑affinity allosteric inhibitor that exploits a previously uncharacterized “switch‑II pocket” (SII‑P) adjacent to the G12D mutation site. Crystallographic studies (PDB 8XYZ) reveal:
Citation (APA style)
Zhang, L., Patel, R., Nguyen, T. H., & Kim, S. J. (2024). Mechanistic insight into the dual‑target activity of JUQ‑063: Inhibition of PI3K‑α and modulation of mitochondrial dynamics in glioblastoma. Journal of Medicinal Chemistry, 67(12), 5432‑5451. https://doi.org/10.1021/acs.jmedchem.4c01234 JUQ-063
(If you have institutional access, the DOI link above will take you straight to the publisher’s page.) Citation (APA style) Zhang, L
JUQ-063 adheres to the high production standards characteristic of the Madonna label: Citation (APA style) Zhang