This tutorial teaches how to plan, design, and deliver a polished project named "JUQ-139" — a concise, repeatable workflow you can adapt to software features, product launches, research tasks, or creative builds. Follow the numbered phases below; each phase lists clear actions, deliverables, tools, and estimated time.
Athymic nude mice (5‑week‑old, n = 8 per group) were subcutaneously implanted with 5 × 10⁶ MDA‑MB‑231 cells in Matrigel. When tumors reached ~150 mm³, mice received either vehicle (0.5 % methylcellulose) or JUQ‑139 (30 mg kg⁻¹, oral, q.d.) for 21 days. Tumor volumes were measured with calipers (V = ½ L × W²) and body weight monitored. At study termination, tumors were excised for immunoblotting of p‑AKT (S473) and Ki‑67. JUQ-139
A convergent synthetic plan was employed (Scheme 1). The benzothiazole fragment (A) was prepared via a Hantzsch condensation, while the pyrazolo[1,5‑a]pyridine fragment (B) was constructed through a cyclocondensation of 2‑aminopyrazine with an appropriate β‑ketoester. The two fragments were linked via a sulfonyl chloride coupling step. Full experimental details are provided in the Supporting Information (SI). This tutorial teaches how to plan, design, and
Scheme 1. Retrosynthetic route to JUQ‑139. JUQ-139, while seemingly obscure or specific, serves as
A (benzothiazole‑aryl bromide) + B (pyrazolo[1,5‑a]pyridine‑amine)
│
N‑Sulfonylation (SO2Cl2, pyridine, 0 °C → rt)
↓
JUQ‑139
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