If you are using the original disc and do not want to use a No-CD patch, you must force Windows to accept the unsigned SecuROM driver. Warning: This lowers the security of your system slightly.
If you absolutely refuse to use a crack and do have a physical USB DVD drive, you can try to force Windows to re-enable the insecure driver. We advise against this for general internet use, but for an offline gaming PC, here is how to do it: pes 6 no cd dvd-rom drive found
The problem: This rarely works on Windows 11 22H2 or newer because Microsoft physically removed the driver files. You will likely get an error saying "The specified service does not exist." If that happens, skip to Method 1 or 3. If you are using the original disc and