Try the following solutions in order. Start with the simplest and move to more advanced steps if needed.
If repair does not work, a clean installation is necessary.
If the runtime libraries are fine, the local AutoCAD profile may be corrupted. problem loading acadres.dll resource file autocad 2021
If the Repair option fails or is greyed out, you should perform a clean reinstall.
AutoCAD 2021’s "Secure Loader" system variable (SECURELOAD) blocks un-trusted DLLs. If the error persists, disable it temporarily. Try the following solutions in order
Warning: Set SECURELOAD back to 1 after testing, as disabling it reduces security against malicious LISP files.
Sometimes, the issue is not AutoCAD but a corrupted Windows VC++ Redistributable or system file that acadres.dll depends on. Restart your PC
Check if your antivirus software has quarantined the file.